Article
Plasma concentration and lipoprotein distribution of ApoC-I is dependent on ApoE genotype rather than the Hpa I ApoC-I promoter polymorphism.
Atherosclerosis - 1 Jul 2003
Cohn Jeffrey S, Tremblay Michel, Boulet Lucie, Jacques Hélène, Davignon Jean, Roy Madeleine, Bernier Lise
Abstract excerpt
An Hpa I restriction site located 317 bp upstream of the transcription initiation site of the apoC-I gene has been shown to increase apoC-I gene transcription in vitro. The aim of the present study was to determine whether this genetic polymorphism was associated in vivo with increased plasma levels of apoC-I. In a cohort of French-Canadians (n=391) recruited for a family study, we found strong linkage...
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