Article
Polyunsaturated fatty acids modulate the effects of the APOA1 G-A polymorphism on HDL-cholesterol concentrations in a sex-specific manner: the Framingham Study.
The American journal of clinical nutrition - 1 Jan 2002
Ordovas Jose M, Corella Dolores, Cupples L Adrienne, Demissie Serkalem, Kelleher Alison, Coltell Oscar, Wilson Peter W F, Schaefer Ernst J, Tucker Katherine
Abstract excerpt
BACKGROUND: A common G-to-A substitution in the promoter area (-75 base pairs) of the apolipoprotein A-I gene (APOA1) has been described. The A allele was shown to be associated with higher HDL-cholesterol concentrations in some studies but not in others. OBJECTIVE: We examined whether dietary fat modulates the association between this polymorphism and HDL-cholesterol concentrations. DESIGN: We studied a...
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