Evidence that the MIF2 gene of Saccharomyces cerevisiae encodes a centromere protein with homology to the mammalian centromere protein CENP-C.

doi:10.1091/mbc.6.7.793

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Article

Evidence that the MIF2 gene of Saccharomyces cerevisiae encodes a centromere protein with homology to the mammalian centromere protein CENP-C.

Molecular biology of the cell - 1 Jul 1995

Meluh P B, Koshland D

Abstract excerpt

The MIF2 gene of Saccharomyces cerevisiae has been implicated in mitosis. Here we provide genetic evidence that MIF2 encodes a centromere protein. Specifically, we found that mutations in MIF2 stabilize dicentric minichromosomes and confer high instability (i.e., a synthetic acentric phenotype) t...

Topics

Amino Acid Sequence
Animals
Basic Helix-Loop-Helix Leucine Zipper Transcription Factors
Centromere
Chromosomal Proteins, Non-Histone
Chromosomes, Fungal
DNA, Fungal
DNA-Binding Proteins
Fungal Proteins
Genes, Fungal
Genes, Suppressor

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Humans

Kinetochores

Mice

Molecular Sequence Data

Mutation

Nuclear Proteins

Saccharomyces cerevisiae

Source

Open in PubMed Open full text

Identifiers

PMID: 7579695
DOI: 10.1091/mbc.6.7.793
PMCID: PMC301241

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-7579695-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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Evidence that the MIF2 gene of Saccharomyces cerevisiae encodes a centromere protein with homology to the mammalian centromere protein CENP-C.PMID 7579695Read ↗

Structural and functional dissection of Mif2p, a conserved DNA-binding kinetochore protein.Semantic proximity Read ↗

MIF2 is required for mitotic spindle integrity during anaphase spindle elongation in Saccharomyces cerevisiae.Semantic proximity Read ↗

Binding of the essential Saccharomyces cerevisiae kinetochore protein Ndc10p to CDEII.Semantic proximity Read ↗

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Identification of essential components of the S. cerevisiae kinetochore.Semantic proximity Read ↗

Histone H2A is required for normal centromere function in Saccharomyces cerevisiae.Semantic proximity Read ↗

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A suppressor of a centromere DNA mutation encodes a putative protein kinase (MCK1).Semantic proximity Read ↗

Fta2, an essential fission yeast kinetochore component, interacts closely with the conserved Mal2 protein.Semantic proximity Read ↗

Functional complementation of human centromere protein A (CENP-A) by Cse4p from Saccharomyces cerevisiae.Semantic proximity Read ↗

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