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Article

A cell cycle-regulated GATA factor promotes centromeric localization of CENP-A in fission yeast.

Molecular cell - 1 Jan 2003

Chen Ee Sin, Saitoh Shigeaki, Yanagida Mitsuhiro, Takahashi Kohta

Abstract excerpt

CENP-A, the centromere-specific histone H3 variant, plays a crucial role in organizing kinetochore chromatin for precise chromosome segregation. We have isolated Ams2, a Daxx-like motif-containing GATA factor, and histone H4, as multicopy suppressors of cnp1-1, an S. pombe CENP-A mutant. While depletion of Ams2 results in the reduction of CENP-A binding to the centromere and chromosome missegregation, increasing...

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PMID: 12535531
DOI: 10.1016/s1097-2765(03)00011-x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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A cell cycle-regulated GATA factor promotes centromeric localization of CENP-A in fission yeast.PMID 12535531Read ↗

A NASP (N1/N2)-related protein, Sim3, binds CENP-A and is required for its deposition at fission yeast centromeres.Semantic proximity Read ↗

Hsk1- and SCF(Pof3)-dependent proteolysis of S. pombe Ams2 ensures histone homeostasis and centromere function.Semantic proximity Read ↗

Mis16 and Mis18 are required for CENP-A loading and histone deacetylation at centromeres.Semantic proximity Read ↗

Mutation of histone H3 serine 86 disrupts GATA factor Ams2 expression and precise chromosome segregation in fission yeast.Semantic proximity Read ↗

Sim4: a novel fission yeast kinetochore protein required for centromeric silencing and chromosome segregation.Semantic proximity Read ↗

Genome-wide analysis reveals a cell cycle-dependent mechanism controlling centromere propagation.Semantic proximity Read ↗

A DNA polymerase alpha accessory protein, Mcl1, is required for propagation of centromere structures in fission yeast.Semantic proximity Read ↗

A Dual Inhibitory Mechanism Sufficient to Maintain Cell-Cycle-Restricted CENP-A Assembly.Semantic proximity Read ↗

Histone H3 lysine 14 acetylation is required for activation of a DNA damage checkpoint in fission yeast.Semantic proximity Read ↗

CENP-H-containing complex facilitates centromere deposition of CENP-A in cooperation with FACT and CHD1.Semantic proximity Read ↗

Fta2, an essential fission yeast kinetochore component, interacts closely with the conserved Mal2 protein.Semantic proximity Read ↗

CENP-C functions as a scaffold for effectors with essential kinetochore functions in mitosis and meiosis.Semantic proximity Read ↗

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