Article
Homozygous deletions but no sequence mutations in coding regions of p15 or p16 in human primary bladder tumors.
Molecular carcinogenesis - 1 Nov 1995
Packenham J P, Taylor J A, Anna C H, White C M, Devereux T R
Abstract excerpt
Chromosome 9p21 appears to harbor a tumor suppressor gene, as evidenced by deletions in this region in a variety of human primary tumors and cell lines. To map the deletion at 9p21 in bladder tumors, we analyzed DNA from 28 tumor and normal pairs at five microsatellite markers that flank the regi...
Topics
- Base Sequence
- Carcinoma, Transitional Cell
- Carrier Proteins
- Cell Cycle Proteins
- Chromosome Mapping
- Chromosomes, Human, Pair 9
- Cyclin-Dependent Kinase Inhibitor p15
- Cyclin-Dependent Kinase Inhibitor p16
- Gene Deletion
- Genes, Tumor Suppressor
- Homozygote
- Humans
- Molecular Sequence Data
- Mutation
- Tumor Suppressor Proteins
- Urinary Bladder Neoplasms