Article
Identification of gains and losses of DNA sequences in primary bladder cancer by comparative genomic hybridization.
Genes, chromosomes & cancer - 1 Mar 1995
Kallioniemi A, Kallioniemi O P, Citro G, Sauter G, DeVries S, Kerschmann R, Caroll P, Waldman F
Abstract excerpt
Comparative genomic hybridization (CGH) makes it possible to detect losses and gains of DNA sequences along all chromosomes in a tumor specimen based on the hybridization of differentially labeled tumor and normal DNA to normal human metaphase chromosomes. In this study, CGH analysis was applied to the identification of genomic imbalances in 26 bladder cancers in order to gain information on the genetic events...
Topics
- Chromosome Mapping
- DNA Mutational Analysis
- DNA, Neoplasm
- Female
- Gene Amplification
- Humans
- In Situ Hybridization, Fluorescence
- Male
- Mutation
- Sequence Deletion
- Urinary Bladder Neoplasms