Decreased expression of the p16/MTS1 gene without mutation is frequent in human urinary bladder carcinomas.

doi:10.1093/jjco/27.1.22

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Article

Decreased expression of the p16/MTS1 gene without mutation is frequent in human urinary bladder carcinomas.

Japanese journal of clinical oncology - 1 Feb 1997

Asamoto M, Iwahori Y, Okamura T, Shirai T, Tsuda H

Abstract excerpt

The p16 (CDKN2,MTS1) gene is located at 9p21 and its product, p16, inhibits the cyclin D/CDK4 complex. Loss of heterozygosity on chromosome 9p is very common in human bladder carcinomas and has been found in all stages of lesions, suggesting that it occurs early in bladder tumor progression. Seve...

Topics

Carrier Proteins
Cyclin-Dependent Kinase Inhibitor p16
DNA Primers
Gene Expression
Humans
Mutation
Polymerase Chain Reaction
Polymorphism, Single-Stranded Conformational
RNA, Messenger
Urinary Bladder Neoplasms

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