Article
Loss of heterozygosity on chromosome 11p13 in primary bladder carcinoma.
Human genetics - 1 Jun 1993
Shipman R, Schraml P, Colombi M, Raefle G, Ludwig C U
Abstract excerpt
Although the occurrence of bladder cancer is common, the molecular events underlying the pathogenesis of this cancer remain ill-defined. A loss of heterozygosity (LOH) at specific chromosomal loci may predispose individuals to the development of bladder cancer but this has not been examined in detail. Furthermore, the role that deletion or inactivation of putative tumour suppressor genes might play in the genesis...
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