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Article

Deletion of the p16 and p15 Genes in Human Bladder Tumors

18 Oct 1995

Abstract excerpt

BACKGROUND: Two genes, p16 (also known as CDKN2, INK4A, or MTS1) and p15 (also described as INK4B or MTS2), are found in tandem at chromosome 9p21. These genes are designated as candidate tumor suppressor genes because they encode proteins that function as negative cell cycle regulators. (The encoded polypeptides inactivate specific cyclin-protein kinase complexes that are required for progression through the...

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PMID: 7563186
DOI: 10.1093/jnci/87.20.1524

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Related research

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Research trail→

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Deletion of the p16 and p15 Genes in Human Bladder TumorsPMID 7563186Read ↗

Infrequent somatic mutations of the p16 and p15 genes in human bladder cancer: p16 mutations occur only in low-grade and superficial bladder cancers.Semantic proximity Read ↗

Homozygous deletions but no sequence mutations in coding regions of p15 or p16 in human primary bladder tumors.Semantic proximity Read ↗

Genetic alterations of p16INK4a and p14ARF genes in human bladder cancer.Semantic proximity Read ↗

p16 (CDKN2) is a major deletion target at 9p21 in bladder cancer.Semantic proximity Read ↗

Decreased expression of the p16/MTS1 gene without mutation is frequent in human urinary bladder carcinomas.Semantic proximity Read ↗

Alteration of p16 and p15 genes in human uterine tumours.Semantic proximity Read ↗

p16 is a major inactivation target in hepatocellular carcinomaSemantic proximity Read ↗

Frequent codeletion of p16/MTS1 and p15/MTS2 and genetic alterations in p16/MTS1 in pancreatic tumors.Semantic proximity Read ↗

Analysis of a family of cyclin-dependent kinase inhibitors: p15/MTS2/INK4B, p16/MTS1/INK4A, and p18 genes in acute lymphoblastic leukemia of childhood.Semantic proximity Read ↗

Loss of P16 expression and chromosome 9p21 LOH in predicting outcome of patients affected by superficial bladder cancer.Semantic proximity Read ↗

Alterations in the tumor suppressor genes p53, RB, p16/MTS1, and p15/MTS2 in human pancreatic cancer and hepatoma cell lines.Semantic proximity Read ↗

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