Apolipoprotein E type epsilon4 allele, heritability and age at onset in twins with Alzheimer disease and vascular dementia.

doi:10.1111/j.1399-0004.1997.tb04362.x

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Article

Apolipoprotein E type epsilon4 allele, heritability and age at onset in twins with Alzheimer disease and vascular dementia.

Clinical genetics - 1 Nov 1997

Bergem A L, Lannfelt L

Abstract excerpt

The apolipoprotein E (APOE) epsilon4 allele is a risk factor in Alzheimer disease (AD), but not in vascular dementia (VaD). We have investigated whether the epsilon4 allele is more common in twin pairs concordant for AD, compared with those discordant for AD, and whether the epsilon4 allele is mo...

Topics

Age of Onset
Alleles
Alzheimer Disease
Apolipoproteins E
Chromosomes
Dementia, Vascular
Gene Frequency
Genotype
Humans
Norway
Risk Factors
Twins

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