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Article

Serial passage of microglial SIV results in selection of homogeneous env quasispecies in the brain.

Virology - 1 Oct 1995

Lane T E, Buchmeier M J, Watry D D, Jakubowski D B, Fox H S

Abstract excerpt

The pathogenic effects of HIV include infection of the central nervous system (CNS) which can result in cognitive and motor dysfunction. Simian immunodeficiency virus (SIV) infection of rhesus macaques provides an excellent model of HIV-induced disease. We have achieved a reproducible infection of the CNS using a stock of virus obtained by serial passage of microglia-associated SIV. Since the envelope genes of...

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Identifiers

PMID: 7571415
DOI: 10.1006/viro.1995.1503

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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