Serial passage of microglial SIV results in selection of homogeneous env quasispecies in the brain.

doi:10.1006/viro.1995.1503

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Article

Serial passage of microglial SIV results in selection of homogeneous env quasispecies in the brain.

Virology - 1 Oct 1995

Lane T E, Buchmeier M J, Watry D D, Jakubowski D B, Fox H S

Abstract excerpt

The pathogenic effects of HIV include infection of the central nervous system (CNS) which can result in cognitive and motor dysfunction. Simian immunodeficiency virus (SIV) infection of rhesus macaques provides an excellent model of HIV-induced disease. We have achieved a reproducible infection o...

Topics

Amino Acid Sequence
Animals
Base Sequence
Cloning, Molecular
Consensus Sequence
DNA, Viral
Encephalitis, Viral
Genes, env
Genetic Variation
Lymph Nodes
Macaca mulatta
Microglia

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Molecular Sequence Data

Sequence Analysis, DNA

Sequence Homology, Amino Acid

Serial Passage

Simian Acquired Immunodeficiency Syndrome

Simian Immunodeficiency Virus

Source

Open in PubMed

Identifiers

PMID: 7571415
DOI: 10.1006/viro.1995.1503

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-7571415-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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