Route of simian immunodeficiency virus inoculation determines the complexity but not the identity of viral variant populations that infect rhesus macaques.

doi:10.1128/JVI.75.8.3753-3765.2001

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Article

Route of simian immunodeficiency virus inoculation determines the complexity but not the identity of viral variant populations that infect rhesus macaques.

Journal of virology - 1 Apr 2001

Greenier J L, Miller C J, Lu D, Dailey P J, Lü F X, Kunstman K J, Wolinsky S M, Marthas M L

Abstract excerpt

A better understanding of the host and viral factors associated with human immunodeficiency virus (HIV) transmission is essential to developing effective strategies to curb the global HIV epidemic. Here we used the rhesus macaque-simian immunodeficiency virus (SIV) animal model of HIV infection to study the range of viral genotypes that are transmitted by different routes of inoculation and by different types of...

Topics

Administration, Intravaginal
Animals
Antibodies, Viral
Female
Genetic Variation
Injections, Intravenous
Macaca mulatta
Male
Molecular Sequence Data
RNA, Viral

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Reverse Transcriptase Polymerase Chain Reaction

Sequence Analysis, DNA

Serial Passage

Simian Acquired Immunodeficiency Syndrome

Simian Immunodeficiency Virus

Stochastic Processes

Viral Load

Viremia

Source

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Identifiers

PMID: 11264364
DOI: 10.1128/JVI.75.8.3753-3765.2001
PMCID: PMC114866

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