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Article

Identification and characterization of a macrophage-tropic SIV envelope glycoprotein variant in blood from early infection in SIVmac251-infected macaques.

Virology - 1 Jun 2014

Yen Po-Jen, Mefford Megan E, Hoxie James A, Williams Kenneth C, Desrosiers Ronald C, Gabuzda Dana

Abstract excerpt

Macrophages play an important role in HIV/SIV pathogenesis by serving as a reservoir for viral persistence in brain and other tissues. Infected macrophages have been detected in brain early after infection, but macrophage-tropic viruses are rarely isolated until late-stage infection. Little is known about early variants that establish persistent infection in brain. Here, we characterize a unique macrophage-tropic...

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Source

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Identifiers

PMID: 24928039
DOI: 10.1016/j.virol.2014.03.024
PMCID: PMC4112485

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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