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Article

Derivation of neurotropic simian immunodeficiency virus from exclusively lymphocytetropic parental virus: pathogenesis of infection in macaques.

Journal of virology - 1 Jun 1992

Sharma D P, Zink M C, Anderson M, Adams R, Clements J E, Joag S V, Narayan O

Abstract excerpt

Neurological disease resulting from lentivirus (including human immunodeficiency virus) infections is usually caused by a strain of virus that replicates productively in microglia in vivo and in macrophage cultures in vitro. We undertook this study using the model of simian immunodeficiency virus in macaques (SIVmac) to test the hypothesis that macrophage tropism is a prerequisite for neurotropism of the virus....

Topics

Adaptation, Biological
Animals
Base Sequence
Brain Diseases
DNA, Viral
Genetic Variation
Histocytochemistry
Lung
Lymphocytes
Macaca mulatta
Macrophages

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Molecular Sequence Data

Organ Specificity

Polymerase Chain Reaction

Simian Acquired Immunodeficiency Syndrome

Simian Immunodeficiency Virus

Source

Open in PubMed Open full text

Identifiers

PMID: 1583723
DOI: 10.1128/JVI.66.6.3550-3556.1992
PMCID: PMC241136

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1583723-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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