Article
Monitoring of azathioprine-induced immunosuppression with thiopurine methyltransferase activity in kidney transplant recipients.
Transplantation - 15 Oct 1995
Mircheva J, Legendre C, Soria-Royer C, Thervet E, Beaune P, Kreis H
Abstract excerpt
Thiopurine methyltransferase (TPMT), one of the enzymes involved in azathioprine metabolism, exhibits a wide range of activity in the normal population. We prospectively evaluated the monitoring of erythrocyte TPMT activity (using a radiochemical method) in kidney transplant recipients with regard to the efficacy of azathioprine. Three patterns in TPMT activity variation were observed. In group 1 patients, TPMT...
Topics
- Azathioprine
- Bone Marrow Diseases
- Erythrocytes
- Evaluation Studies as Topic
- Genotype
- Glutathione Transferase
- Humans
- Immunosuppressive Agents
- Kidney Transplantation
- Mercaptopurine
- Methyltransferases