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Article

Thiopurine methyltransferase activity and its relationship to the occurrence of rejection episodes in paediatric renal transplant recipients treated with azathioprine.

British journal of clinical pharmacology - 1 Dec 1999

Dervieux T, Médard Y, Baudouin V, Maisin A, Zhang D, Broly F, Loirat C, Jacqz-Aigrain E

Abstract excerpt

AIMS: Azathioprine is a prodrug commonly used in combination therapy to prevent allograft rejection after renal transplantation. After conversion to 6-mercaptopurine, the drug is metabolized into 6-thioguanine nucleotides (6-TGN) and catabolized by thiopurine methyltransferase (TPMT), an enzyme under monogenic control. The aim of this study was to evaluate the inter- and intraindividual variability of red blood...

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Identifiers

PMID: 10594482
DOI: 10.1046/j.1365-2125.1999.00087.x
PMCID: PMC2014314

Genes

TPMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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