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Article

TPMT genetic variants are associated with increased rejection with azathioprine use in heart transplantation.

Pharmacogenetics and genomics - 1 Dec 2013

Liang Jackson J, Geske Jennifer R, Boilson Barry A, Frantz Robert P, Edwards Brooks S, Kushwaha Sudhir S, Kremers Walter K, Weinshilboum Richard M, Pereira Naveen L

Abstract excerpt

OBJECTIVES: Azathioprine (AZA) is an important immunosuppressant drug used in heart transplantation (HTX). Consensus guidelines recommend that patients with thiopurine S-methyltransferase (TPMT) genetic variants be started on lower AZA dose because of higher active metabolite levels and risk of adverse events. However, in-vitro lymphocyte proliferation assays performed in participants with inactive TPMT alleles...

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Source

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Identifiers

PMID: 24121523
DOI: 10.1097/FPC.0000000000000005
PMCID: PMC3894785

Genes

TPMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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