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Article

Relationships between thiopurine S-methyltransferase polymorphism and azathioprine-related adverse drug reactions in Chinese renal transplant recipients.

European journal of clinical pharmacology - 1 Mar 2009

Xin Hua-Wen, Xiong Hui, Wu Xiao-Chun, Li Qing, Xiong Lei, Yu Ai-Rong

Abstract excerpt

OBJECTIVE: To systematically investigate the relationships between thiopurine S-methyltransferase (TPMT) polymorphisms and azathioprine-related adverse drug reactions in patients with kidney transplantation. METHODS: Erythrocyte TPMT activity of 150 patients with kidney transplantation and AZA therapy was determined by HPLC. The frequency of four common TPMT mutant alleles, TPMT*2, *3A, *3B, and *3C was...

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Source

Identifiers

PMID: 19048245
DOI: 10.1007/s00228-008-0589-0

Genes

TPMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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