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Article

Monitoring of thiopurine methyltransferase activity in postsurgical patients with Crohn's disease during 1 year of treatment with azathioprine or mesalazine.

Therapeutic drug monitoring - 1 Feb 2007

Dilger Karin, Schaeffeler Elke, Lukas Milan, Strauch Ulrike, Herfarth Hans, Müller Ralph, Schwab Matthias

Abstract excerpt

Thiopurine methyltransferase (TPMT) activity determines biotransformation of azathioprine and, thereby, drug efficacy and safety. Evaluation of a possible long-term effect of mesalazine or azathioprine on TPMT activity is of particular clinical importance because both drugs can to be given for several years in inflammatory bowel disease. Monitoring of TPMT activity and three thiopurine metabolites was performed...

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Source

Identifiers

PMID: 17304143
DOI: 10.1097/FTD.0b013e3180312b9a

Genes

TPMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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