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Article

Fast and slow methylators: do racial differences influence risk of allograft rejection?

The Quarterly journal of medicine - 1 Jun 1993

Chocair P R, Duley J A, Sabbaga E, Arap S, Simmonds H A, Cameron J S

Abstract excerpt

A catabolic route for azathioprine involving methylation by thiopurine methyltransferase has been directly implicated in the drug's immunosuppressive efficacy. Since ethnic differences in thiopurine methyltransferase activity have been reported in a study of Lapps, this study compared the distribution of thiopurine methyltransferase activity in erythrocyte lysates from 134 healthy, randomly selected subjects...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 8171183

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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Fast and slow methylators: do racial differences influence risk of allograft rejection?PMID 8171183Read ↗

Interethnic difference in thiopurine methyltransferase activity.Semantic proximity Read ↗

Thiopurine methyltransferase: should it be measured before commencing thiopurine drug therapy?Semantic proximity Read ↗

Ethnic variation of thiopurine S-methyltransferase activity: a large, prospective population study.Semantic proximity Read ↗

Thiopurine S-methyltransferase genotype predicts azathioprine-induced myelotoxicity in kidney transplant recipients.Semantic proximity Read ↗

TPMT genetic variants are associated with increased rejection with azathioprine use in heart transplantation.Semantic proximity Read ↗

Thiopurine methyltransferase phenotypes and genotypes in Brazilians.Semantic proximity Read ↗

Thiopurine methyltransferase genotype and activity cannot predict outcomes of azathioprine maintenance therapy for antineutrophil cytoplasmic antibody associated vasculitis: A retrospective cohort study.Semantic proximity Read ↗

6-Mercaptopurine pharmacokinetics after use of azathioprine in renal transplant recipients with intermediate or high thiopurine methyl transferase activity phenotype.Semantic proximity Read ↗

Azathioprine toxicity and thiopurine methyltransferase genotype in renal transplant patients.Semantic proximity Read ↗

Monitoring of azathioprine-induced immunosuppression with thiopurine methyltransferase activity in kidney transplant recipients.Semantic proximity Read ↗

Thiopurine methyltransferase activity and its relationship to the occurrence of rejection episodes in paediatric renal transplant recipients treated with azathioprine.Semantic proximity Read ↗

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