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Article

Fast and slow methylators: do racial differences influence risk of allograft rejection?

The Quarterly journal of medicine - 1 Jun 1993

Chocair P R, Duley J A, Sabbaga E, Arap S, Simmonds H A, Cameron J S

Abstract excerpt

A catabolic route for azathioprine involving methylation by thiopurine methyltransferase has been directly implicated in the drug's immunosuppressive efficacy. Since ethnic differences in thiopurine methyltransferase activity have been reported in a study of Lapps, this study compared the distribution of thiopurine methyltransferase activity in erythrocyte lysates from 134 healthy, randomly selected subjects...

Topics

Adult
Aged
Erythrocytes
Female
Graft Rejection
Humans
Male
Methylation
Methyltransferases
Middle Aged
Phenotype
Polymorphism, Genetic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Racial Groups

Transplantation, Homologous

Source

Identifiers

PMID: 8171183

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-8171183-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Fast and slow methylators: do racial differences influence risk of allograft rejection?PMID 8171183Read ↗

Interethnic difference in thiopurine methyltransferase activity.Semantic proximity Read ↗

Thiopurine methyltransferase: should it be measured before commencing thiopurine drug therapy?Semantic proximity Read ↗

Ethnic variation of thiopurine S-methyltransferase activity: a large, prospective population study.Semantic proximity Read ↗

Thiopurine S-methyltransferase genotype predicts azathioprine-induced myelotoxicity in kidney transplant recipients.Semantic proximity Read ↗

TPMT genetic variants are associated with increased rejection with azathioprine use in heart transplantation.Semantic proximity Read ↗

Thiopurine methyltransferase phenotypes and genotypes in Brazilians.Semantic proximity Read ↗

Thiopurine methyltransferase genotype and activity cannot predict outcomes of azathioprine maintenance therapy for antineutrophil cytoplasmic antibody associated vasculitis: A retrospective cohort study.Semantic proximity Read ↗

6-Mercaptopurine pharmacokinetics after use of azathioprine in renal transplant recipients with intermediate or high thiopurine methyl transferase activity phenotype.Semantic proximity Read ↗

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Monitoring of azathioprine-induced immunosuppression with thiopurine methyltransferase activity in kidney transplant recipients.Semantic proximity Read ↗

Thiopurine methyltransferase activity and its relationship to the occurrence of rejection episodes in paediatric renal transplant recipients treated with azathioprine.Semantic proximity Read ↗

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