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Article

A new look at the role of p53 in leukemia cell sensitivity to chemotherapy.

Leukemia - 1 Nov 1997

Trepel M, Scheding S, Groscurth P, Horny H P, Malipiero U, Brugger W, Dichgans J, Weller M

Abstract excerpt

A gene encoding the p53 val135 mutant, which assumes mutant conformation at 38.5 degrees C and wild-type conformation at 32.5 degrees C, was introduced into p53-deficient K562 myeloid leukemia cells. Forced expression of wild-type, but not mutant, p53 resulted in growth arrest, accumulation of p21 and Bax proteins, and delayed cell death. Wild-type p53 enhanced the cytotoxic effects of some drugs and attenuated...

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Identifiers

PMID: 9369416
DOI: 10.1038/sj.leu.2400824

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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