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Article

Differential regulation of the IL-17 receptor by gammac cytokines: inhibitory signaling by the phosphatidylinositol 3-kinase pathway.

The Journal of biological chemistry - 16 May 2008

Lindemann Matthew J, Hu Zihua, Benczik Marta, Liu Kathleen D, Gaffen Sarah L

Abstract excerpt

The gammac-family cytokine IL-2 activates signaling events that contribute to cell survival and proliferation, the best-studied of which are the STAT-5 and phosphatidylinositol 3-kinase (PI3K) pathways. The starting point of this study was to define genes regulated by the IL-2R-mediated PI3K path...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Phosphatidylinositol 3-Kinases

Share to Receptors, Interleukin-17

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Source

Open in PubMed Open full text

Identifiers

PMID: 18348982
DOI: 10.1074/jbc.M801357200
PMCID: PMC2376247

Genes

EPO
JAK1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-18348982-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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