Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Plasmid-based transgenic mouse model for studying in vivo mutations.

Nature - 19 Oct 1995

Boerrigter M E, Dollé M E, Martus H J, Gossen J A, Vijg J

Abstract excerpt

A new transgenic mouse model for studying in vivo somatic mutations is based on the efficient recovery of chromosomally integrated lacZ-containing plasmids, using magnetic beads.

Topics

Animals
Bacteriophage lambda
Lac Operon
Mice
Mice, Inbred C57BL
Mice, Transgenic
Models, Genetic
Mutation
Plasmids

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 7566182
DOI: 10.1038/377657a0
PMCID: PMC12990988

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7566182-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Plasmid-based transgenic mouse model for studying in vivo mutations.PMID 7566182Read ↗

Detection and analysis of somatic mutations at a lacZ reporter locus in higher organisms: application to Mus musculus and Drosophila melanogaster.Semantic proximity Read ↗

Insertional mutagenesis in transgenic mice.Semantic proximity Read ↗

Transgenic mice as model systems for studying gene mutations in vivo.Semantic proximity Read ↗

Evaluation of a plasmid-based transgenic mouse model for detecting in vivo mutations.Semantic proximity Read ↗

Simple and straightforward construction of a mouse gene targeting vector using in vitro transposition reactions.Semantic proximity Read ↗

Use of transgenic mouse models for studying somatic mutations in aging.Semantic proximity Read ↗

Exchangeable gene trap using the Cre/mutated lox system.Semantic proximity Read ↗

Spontaneous and X-ray-induced deletion mutations in a LacZ plasmid-based transgenic mouse model.Semantic proximity Read ↗

Generation of transgenic mice.Semantic proximity Read ↗

Transgenic animal models for measuring mutations in vivo.Semantic proximity Read ↗

Transgenic mice as models for heritable diseases.Semantic proximity Read ↗

Utilization of microhomologous recombination in yeast to generate targeting constructs for mammalian genes.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.