Transgenic animal models for measuring mutations in vivo.

doi:10.3109/10408449409021608

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Article

Transgenic animal models for measuring mutations in vivo.

Critical reviews in toxicology - 1 Jan 1994

Mirsalis J C, Monforte J A, Winegar R A

Abstract excerpt

Transgenic animal models for measuring mutations provide a powerful tool for rapidly assessing tissue-specific mutations following in vivo treatment. These models are based on the insertion into the rodent genome of the Escherichia coli lacI (lac repressor) or lacZ (beta-galactosidase) genes that...

Topics

Animals
Animals, Genetically Modified
Mutagenesis
Mutation

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