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Article

Transgenic animal models for measuring mutations in vivo.

Critical reviews in toxicology - 1 Jan 1994

Mirsalis J C, Monforte J A, Winegar R A

Abstract excerpt

Transgenic animal models for measuring mutations provide a powerful tool for rapidly assessing tissue-specific mutations following in vivo treatment. These models are based on the insertion into the rodent genome of the Escherichia coli lacI (lac repressor) or lacZ (beta-galactosidase) genes that serve as targets for mutations. Following in vivo treatment of animals, genomic DNA is isolated from various tissues...

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PMID: 7945893
DOI: 10.3109/10408449409021608

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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