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Article

Influence of sex, smoking and age on human hprt mutation frequencies and spectra.

Genetics - 1 Jul 1999

Curry J, Karnaoukhova L, Guenette G C, Glickman B W

Abstract excerpt

Examination of the literature for hprt mutant frequencies from peripheral T cells yielded data from 1194 human subjects. Relationships between mutant frequency, age, sex, and smoking were examined, and the kinetics were described. Mutant frequency increases rapidly with age until about age 15. Afterward, the rate of increase falls such that after age 53, the hprt mutant frequency is largely stabilized. Sex had no...

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Identifiers

PMID: 10388825
DOI: 10.1093/genetics/152.3.1065
PMCID: PMC1460655

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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