Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Increased thermosensitivity associated with topoisomerase I deletion and promoter mutations in Escherichia coli.

FEMS microbiology letters - 1 Sept 1999

Qi H, Menzel R, Tse-Dinh Y C

Abstract excerpt

An Escherichia coli mutant with three of the promoters for the topoisomerase I gene (topA) deleted, such that only the sigma 32-dependent promoter (P1) remained, had a decreased level of topoisomerase I at 30 degrees C and showed increased thermosensitivity at 52 degrees C. However, it could still develop thermotolerance and had a wild-type level of resistance to 52 degrees C treatment if exposed first to 42...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to DNA Topoisomerases, Type I
Share to Escherichia coli
Share to Gene Deletion

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Genes, Bacterial

Share to Genotype

Share to Hot Temperature

Share to Promoter Regions, Genetic

Share to Sigma Factor

Source

Identifiers

PMID: 10483733
DOI: 10.1111/j.1574-6968.1999.tb13770.x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Increased thermosensitivity associated with topoisomerase I deletion and promoter mutations in Escherichia coli.PMID 10483733Read ↗

RNase H overproduction allows the expression of stress-induced genes in the absence of topoisomerase I.Semantic proximity Read ↗

Viability of Escherichia coli topA mutants lacking DNA topoisomerase I.Semantic proximity Read ↗

On the molecular basis of the thermal sensitivity of an Escherichia coli topA mutant.Semantic proximity Read ↗

A grpE mutant of Escherichia coli is more resistant to heat than the wild-type.Semantic proximity Read ↗

DNA supercoiling in a thermotolerant mutant of Escherichia coli.Semantic proximity Read ↗

Conversion of temperature-sensitive to -resistant gene expression due to mutations in the promoter region of the melibiose operon in Escherichia coli.Semantic proximity Read ↗

Gene expression profiling of intrinsic thermotolerance in Escherichia coli.Semantic proximity Read ↗

Overexpression of the Shigella flexneri genes coding for DNA topoisomerase IV compensates for loss of DNA topoisomerase I: effect on virulence gene expression.Semantic proximity Read ↗

Mutants with higher stability and specific activity from a single thermosensitive variant of T7 RNA polymerase.Semantic proximity Read ↗

Escherichia coli tyrT gene transcription is sensitive to DNA supercoiling in its native chromosomal context: effect of DNA topoisomerase IV overexpression on tyrT promoter function.Semantic proximity Read ↗

Novel Escherichia coli mutant, dnaR, thermosensitive in initiation of chromosome replication.Semantic proximity Read ↗

Modulation of gene expression by promoter mutants of the lambdacI857/pRM/pR system.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.