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A genetic selection for supercoiling mutants of Escherichia coli reveals proteins implicated in chromosome structure.

Molecular microbiology - 1 Sept 2005

Hardy Christine D, Cozzarelli Nicholas R

Abstract excerpt

Chromosomes are divided into topologically independent regions, called domains, by the action of uncharacterized barriers. With the goal of identifying domain barrier components, we designed a genetic selection for mutants with reduced negative supercoiling of the Escherichia coli chromosome. We employed a strain that contained two chromosomally located reporter genes under the control of a supercoiling-sensitive...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Escherichia coli Proteins

Share to Gene Expression Regulation, Bacterial

Share to Mutagenesis, Insertional

Share to Oligonucleotide Array Sequence Analysis

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Source

Identifiers

PMID: 16135230
DOI: 10.1111/j.1365-2958.2005.04799.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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