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Article

Genomic transcriptional response to loss of chromosomal supercoiling in Escherichia coli.

Genome biology - 1 Jan 2004

Peter Brian J, Arsuaga Javier, Breier Adam M, Khodursky Arkady B, Brown Patrick O, Cozzarelli Nicholas R

Abstract excerpt

BACKGROUND: The chromosome of Escherichia coli is maintained in a negatively supercoiled state, and supercoiling levels are affected by growth phase and a variety of environmental stimuli. In turn, supercoiling influences local DNA structure and can affect gene expression. We used microarrays representing nearly the entire genome of Escherichia coli MG1655 to examine the dynamics of chromosome structure. RESULTS:...

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Identifiers

PMID: 15535863
DOI: 10.1186/gb-2004-5-11-r87
PMCID: PMC545778

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Source receipt: pubmed, retrieved 7 Sept 2026.

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