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In Vitro Processing of Human Tumor Necrosis Factor-α

1 Oct 1995

Abstract excerpt

Tumor necrosis factor (TNF)-alpha is initially synthesized as a membrane-bound, cell-associated 26-kDa protein that is further cleaved to yield the soluble 17-kDa form. By using a radiolabeled in vitro translated TNF-alpha precursor we detected a serine proteinase processing activity present in crude membrane preparations of monocytic cells able to generate a 17-kDa active protein. A similar processing pattern...

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PMID: 7559538
DOI: 10.1074/jbc.270.40.23688

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