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Article

Length of the linking domain of human pro-tumor necrosis factor determines the cleavage processing.

Biochemistry - 25 Jun 1996

Tang P, Hung M-C, Klostergaard J

Abstract excerpt

Several studies have indicated that only one cleavage site (Ala-1/Val+1) is involved in the release of mature TNF from human pro-TNF, whereas others have suggested that the linking sequence (residues -20 to -1) may be important. We previously demonstrated that a pro-TNF deletion mutant, delta -20- -1, was able to form a trimeric structure and mediate TNF cytotoxicity in a juxtacrine fashion without releasing...

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Identifiers

PMID: 8679577
DOI: 10.1021/bi952183l

Genes

TNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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