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Article

Signal and propeptide processing of human tissue plasminogen activator: activity of a pro-tPA derivative.

Biochemical and biophysical research communications - 30 Sept 1991

Berg D T, Grinnell B W

Abstract excerpt

We have explored the heterogeneity in the proteolytic processing of the N-terminus of human tissue plasminogen activator. We demonstrate that normal propeptide processing occurs following Arg-4, preceding the sequence Gly-Ala-Arg-Ser+1. Generation of the previously designated Ser+1 occurs via secondary proteolysis following secretion. By site-directed mutagenesis, we have eliminated this cleavage site resulting...

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PMID: 1930175
DOI: 10.1016/0006-291x(91)91713-m

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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