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Article

Apoptosis-related fragmentation, translocation, and properties of human prothymosin alpha.

Experimental cell research - 1 Apr 2003

Evstafieva Alexandra G, Belov George A, Rubtsov Yuri P, Kalkum Markus, Joseph Bertrand, Chichkova Nina V, Sukhacheva Elena A, Bogdanov Alexey A, Pettersson Ralf F, Agol Vadim I, Vartapetian Andrey B

Abstract excerpt

Human prothymosin alpha is a proliferation-related nuclear protein undergoing caspase-mediated fragmentation in apoptotic cells. We show here that caspase-3 is the principal executor of prothymosin alpha fragmentation in vivo. In apoptotic HeLa cells as well as in vitro, caspase-3 cleaves prothymosin alpha at one major carboxy terminal (DDVD(99)) and several suboptimal sites. Prothymosin alpha cleavage at two...

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Identifiers

PMID: 12651154
DOI: 10.1016/s0014-4827(02)00047-2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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