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Article

Processing of alpha4 integrin by the proprotein convertases: histidine at position P6 regulates cleavage.

The Biochemical journal - 15 Jul 2003

Bergeron Eric, Basak Ajoy, Decroly Etienne, Seidah Nabil G

Abstract excerpt

The proprotein convertases (PCs) participate in the limited proteolysis of integrin alpha4 subunit at the H(592)VISKR(597) downward arrow ST site (where underlined residues indicate positively charged amino acids important for PC-mediated cleavage and downward arrow indicates the cleavage site), since this cleavage is inhibited by the serpin alpha1-PDX (alpha1-antitrypsin Portland). Co-expression of alpha4 with...

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Identifiers

PMID: 12691605
DOI: 10.1042/BJ20021630
PMCID: PMC1223497

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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