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Article

Cleavage of p21/WAF1/CIP1 by proteinase 3 modulates differentiation of a monocytic cell line. Molecular analysis of the cleavage site.

The Journal of biological chemistry - 26 Aug 2005

Dublet Bernard, Ruello Antonella, Pederzoli Magali, Hajjar Eric, Courbebaisse Marie, Canteloup Sandrine, Reuter Nathalie, Witko-Sarsat Véronique

Abstract excerpt

Proteinase 3 (PR3), also called myeloblastin, is involved in the control of myeloid cell growth, but the underlying molecular mechanisms have not been elucidated. In U937/PR3, stably transfected with PRCRSV/PR3 to overexpress PR3, PMA-induced p21 expression was significantly decreased as compared with control U937, and this phenomenon was reversed in the presence of the serine proteinase inhibitor, pefabloc....

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Identifiers

PMID: 15975933
DOI: 10.1074/jbc.M414609200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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