Mutations in the reduced folate carrier gene which confer dominant resistance to 5,10-dideazatetrahydrofolate.

doi:10.1074/jbc.273.40.25953

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Article

Mutations in the reduced folate carrier gene which confer dominant resistance to 5,10-dideazatetrahydrofolate.

The Journal of biological chemistry - 2 Oct 1998

Tse A, Brigle K, Taylor S M, Moran R G

Abstract excerpt

L1210/D3 mouse leukemia cells are resistant to 5, 10-dideazatetrahydrofolate due to expansion of cellular folate pools which block polyglutamation of the drug (Tse, A., and Moran, R. G. (1998) J. Biol. Chem. 273, 25944-25952). These cells were found to have two point mutations in the reduced fola...

Topics

Animals
Biological Transport
Carrier Proteins
Cell Division
DNA Mutational Analysis
Drug Resistance
Folate Receptors, GPI-Anchored
Folic Acid
Kinetics
Leucovorin
Leukemia L1210
Methotrexate
Mice
Phenotype
Point Mutation
Pteroylpolyglutamic Acids
RNA, Messenger
Receptors, Cell Surface

Source

Open in PubMed

Identifiers

PMID: 9748272
DOI: 10.1074/jbc.273.40.25953

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9748272-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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