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Article

Loss of multidrug resistance protein 1 expression and folate efflux activity results in a highly concentrative folate transport in human leukemia cells.

The Journal of biological chemistry - 28 Feb 2003

Assaraf Yehuda G, Rothem Lilah, Hooijberg Jan Hendrik, Stark Michal, Ifergan Ilan, Kathmann Ietje, Dijkmans Ben A C, Peters Godefridus J, Jansen Gerrit

Abstract excerpt

We studied the molecular basis of the up to 46-fold increased accumulation of folates and methotrexate (MTX) in human leukemia CEM-7A cells established by gradual deprivation of leucovorin (LCV). CEM-7A cells consequently exhibited 10- and 68-fold decreased LCV and folic acid growth requirements and 23-25-fold hypersensitivity to MTX and edatrexate. Although CEM-7A cells displayed a 74-86-fold increase in the...

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PMID: 12486126
DOI: 10.1074/jbc.M209186200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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