Article
Interaction between HLA-DR and HLA-DP, and between HLA and interleukin 1 alpha in juvenile rheumatoid arthritis indicates heterogeneity of pathogenic mechanisms of the disease.
Human immunology - 1 Apr 1995
Ploski R, McDowell T L, Symons J A, Flatø B, Duff G W, Thorsby E, Førre O
Abstract excerpt
EOP-JRA is an autoimmune disease that displays associations with DPB1*0201, DR8, DR5, and DR6, as well as an association with IL1A2 (a variant of IL1 alpha gene, not HLA linked). The purpose of this study was to analyze interactions between these genetic factors. We studied 103 EOP-JRA patients,...
Topics
- Alleles
- Arthritis, Juvenile
- Base Sequence
- Child
- Child, Preschool
- Female
- Genetic Predisposition to Disease
- HLA-DP Antigens
- HLA-DR Antigens
- Humans
- Infant
- Interleukin-1
- Male
- Molecular Sequence Data
- Risk Factors