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Article

A distinct HLA-DRw8 haplotype characterizes patients with juvenile rheumatoid arthritis.

Immunogenetics - 1 Jan 1990

Van Kerckhove C, Melin-Aldana H, Elma M S, Luyrink L, Donnelly P, Taylor J, Maksymowych W P, Lovell D J, Choi E, Glass D N

Abstract excerpt

We studied the first domain of the HLA-DRB1, HLA-DQA1, and HLA-DQB1 loci of 67 HLA-DRw8-positive Caucasians including 43 with early-onset pauciarticular juvenile rheumatoid arthritis (EOPA-JRA, alternatively known as early-onset pauciarticular juvenile chronic arthritis). Serology, restriction fragment length polymorphism (RFLP), and polymerase chain reaction (PCR) oligotyping revealed that 62, including all the...

Topics

Arthritis, Juvenile
Base Sequence
Follow-Up Studies
Genotype
HLA-DQ Antigens
HLA-DR Antigens
HLA-DR Serological Subtypes
Haplotypes
Humans
Molecular Sequence Data
Polymerase Chain Reaction

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Polymorphism, Restriction Fragment Length

White People

Source

Identifiers

PMID: 1979063
DOI: 10.1007/BF00211643

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1979063-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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