Article
Juvenile idiopathic arthritis and HLA class I and class II interactions and age-at-onset effects.
Arthritis and rheumatism - 1 Jun 2010
Hollenbach Jill A, Thompson Susan D, Bugawan Teodorica L, Ryan Mary, Sudman Marc, Marion Miranda, Langefeld Carl D, Thomson Glenys, Erlich Henry A, Glass David N
Abstract excerpt
OBJECTIVE: The aim of this study was to quantitate risk and to examine heterogeneity for HLA at high resolution in patients with the most common subtypes of juvenile idiopathic arthritis (JIA), IgM rheumatoid factor-negative polyarticular JIA and oligoarticular JIA. Use of 4-digit comprehensive HLA typing enabled great precision, and a large cohort allowed for consideration of both age at disease onset and...
Topics
- Adolescent
- Age Factors
- Age of Onset
- Alleles
- Arthritis, Juvenile
- Case-Control Studies
- Child
- Child, Preschool
- Female
- Gene Frequency
- Genetic Predisposition to Disease
- Haplotypes
- Histocompatibility Antigens Class I