Article
HLA-DR/DQ/DP interactions in rheumatoid arthritis.
European journal of immunogenetics : official journal of the British Society for Histocompatibility and Immunogenetics - 1 Oct 1997
Seidl C, Koch U, Brünnler G, Buhleier T, Frank R, Möller B, Markert E, Koller-Wagner G, Seifried E, Kaltwasser J P
Abstract excerpt
Rheumatoid arthritis (RA) is associated with the presence of particular HLA-DRB1 alleles. In order to characterize HLA-DQB1 and/or-DPB1 alleles that contribute to disease susceptibility besides HLA-DRB1 alleles, we have analysed the HLA-DRB1, -DQB1 and -DPB1 polymorphism in 84 RA patients and 135...
Topics
- Adult
- Aged
- Alleles
- Amino Acid Substitution
- Arthritis, Rheumatoid
- Disease Susceptibility
- Female
- Gene Frequency
- HLA-DP Antigens
- HLA-DP beta-Chains
- HLA-DQ Antigens
- HLA-DQ beta-Chains
- HLA-DR Antigens
- HLA-DRB1 Chains
- Haplotypes
- Humans
- Linkage Disequilibrium
- Male