Article
Avirulence of a Pseudomonas aeruginosa algC mutant in a burned-mouse model of infection.
Infection and immunity - 1 Oct 1995
Goldberg J B, Coyne M J, Neely A N, Holder I A
Abstract excerpt
The virulence of wild-type Pseudomonas aeruginosa PAO1 and that of a genetically defined algC mutant, PAO1 algC::tet, were compared in a burned-mouse model of infection. Unlike PAO1, PAO1 algC::tet was avirulent, grew less well in the eschar, and did not disseminate to the liver of challenged animals. We have previously shown that the P. aeruginosa algC gene is required for biosynthesis of alginate and...
Topics
- Animals
- Burns
- Female
- Lipopolysaccharides
- Mice
- Mutation
- Phosphoglucomutase
- Phosphotransferases (Phosphomutases)
- Pseudomonas Infections
- Pseudomonas aeruginosa
- Virulence