Contribution of the regulatory gene lasR to the pathogenesis of Pseudomonas aeruginosa infection of burned mice.

doi:10.1097/00004630-199901001-00008

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Article

Contribution of the regulatory gene lasR to the pathogenesis of Pseudomonas aeruginosa infection of burned mice.

The Journal of burn care & rehabilitation - 1 Jan 2000

Rumbaugh K P, Griswold J A, Hamood A N

Abstract excerpt

Pseudomonas aeruginosa is a gram-negative opportunistic pathogen that causes severe infections in patients with burns. The P aeruginosa regulatory gene, lasR, regulates the expression of several virulence factors. The specific lasR isogenic mutant, PAO-R1, is defective in the synthesis of the 2 e...

Topics

Animals
Burns
Female
Genes, Regulator
Mice
Mice, Inbred Strains
Mutation
Pseudomonas Infections
Pseudomonas aeruginosa
Skin
Virulence
Wound Infection

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