Article
Deletion of algK in mucoid Pseudomonas aeruginosa blocks alginate polymer formation and results in uronic acid secretion.
Journal of bacteriology - 1 Feb 1998
Jain S, Ohman D E
Abstract excerpt
Chronic pulmonary infection with Pseudomonas aeruginosa is a common and serious problem in patients with cystic fibrosis (CF). The P. aeruginosa isolates from these patients typically have a mucoid colony morphology due to overproduction of the exopolysaccharide alginate, which contributes to the...
Topics
- Alginates
- Bacterial Proteins
- Cloning, Molecular
- Cytoplasm
- Escherichia coli
- Gene Deletion
- Gene Expression
- Glucuronic Acid
- Hexuronic Acids
- Mannose-6-Phosphate Isomerase
- Molecular Sequence Data
- Multienzyme Complexes
- Mutagenesis
- Nucleotidyltransferases
- Phenotype
- Polymers
- Pseudomonas aeruginosa
- Sequence Analysis, DNA