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Article

Role of an alginate lyase for alginate transport in mucoid Pseudomonas aeruginosa.

Infection and immunity - 1 Oct 2005

Jain Sumita, Ohman Dennis E

Abstract excerpt

The opportunistic pathogen Pseudomonas aeruginosa secretes a capsule-like polysaccharide called alginate that is important for evasion of host defenses, especially during chronic pulmonary disease of patients with cystic fibrosis (CF). Most proteins for alginate biosynthesis are encoded by the 12-gene algD operon. Interestingly, this operon also encodes AlgL, a lyase that degrades alginate. Mutants lacking AlgG,...

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Identifiers

PMID: 16177314
DOI: 10.1128/IAI.73.10.6429-6436.2005
PMCID: PMC1230907

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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Role of an alginate lyase for alginate transport in mucoid Pseudomonas aeruginosa.PMID 16177314Read ↗

The Pseudomonas aeruginosa homeostasis enzyme AlgL clears the periplasmic space of accumulated alginate during polymer biosynthesisSemantic proximity Read ↗

Deletion of algK in mucoid Pseudomonas aeruginosa blocks alginate polymer formation and results in uronic acid secretion.Semantic proximity Read ↗

Outer-membrane protein LptD (PA0595) plays a role in the regulation of alginate synthesis in Pseudomonas aeruginosa.Semantic proximity Read ↗

ClpXP proteases positively regulate alginate overexpression and mucoid conversion in Pseudomonas aeruginosa.Semantic proximity Read ↗

AlgX Is a Periplasmic Protein Required for Alginate Biosynthesis in <i>Pseudomonas aeruginosa</i>Semantic proximity Read ↗

Alginate lyase (AlgL) activity is required for alginate biosynthesis in Pseudomonas aeruginosa.Semantic proximity Read ↗

Mechanism of conversion to mucoidy in Pseudomonas aeruginosa infecting cystic fibrosis patients.Semantic proximity Read ↗

A complex multilevel attack on Pseudomonas aeruginosa algT/U expression and algT/U activity results in the loss of alginate production.Semantic proximity Read ↗

Genetic analysis of the alginate biosynthetic gene cluster of <i>Pseudomonas aeruginosa</i> shows evidence of an operonic structureSemantic proximity Read ↗

Pseudomonas aeruginosa Regulated Intramembrane Proteolysis: Protease MucP Can Overcome Mutations in the AlgO Periplasmic Protease To Restore Alginate Production in Nonmucoid Revertants.Semantic proximity Read ↗

Overproduction of the AlgT Sigma Factor Is Lethal to Mucoid Pseudomonas aeruginosa.Semantic proximity Read ↗

Transcriptional analysis of the Pseudomonas aeruginosa genes algR, algB, and algD reveals a hierarchy of alginate gene expression which is modulated by algT.Semantic proximity Read ↗

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