Article
Virulence properties of Pseudomonas aeruginosa lacking the extreme-stress sigma factor AlgU (sigmaE).
Infection and immunity - 1 Jul 1996
Yu H, Boucher J C, Hibler N S, Deretic V
Abstract excerpt
A discerning feature of Pseudomonas aeruginosa strains causing chronic endobronchial infections in cystic fibrosis is their conversion into the mucoid, exopolysaccharide alginate-overproducing phenotype. This morphologically prominent change is caused by mutations which upregulate AlgU (sigma(E))...
Topics
- Animals
- Bacterial Proteins
- Blood Bactericidal Activity
- Cystic Fibrosis
- Disease Models, Animal
- Humans
- Hypochlorous Acid
- In Vitro Techniques
- Mice
- Mice, Inbred C3H
- Mice, Inbred C57BL
- Mutation
- Opportunistic Infections
- Pseudomonas Infections
- Pseudomonas aeruginosa
- Sepsis
- Sigma Factor
- Virulence