Article
Sequence specificity in the higher-order interaction of the Rev protein of HIV-1 with its target sequence, the RRE.
Journal of acquired immune deficiency syndromes and human retrovirology : official publication of the International Retrovirology Association - 1 Nov 1995
Powell D M, Zhang M J, Konings D A, Wingfield P T, Stahl S J, Dayton E T, Dayton A I
Abstract excerpt
The Rev protein of human immunodeficiency virus type 1 (HIV-1) multimerizes along RNAs containing the Rev target sequence, the RRE. Although sequence-specific information is recognized in the high affinity or initial interaction, it is not known what role RNA-contained information plays in higher-order binding events. We have quantitatively studied the binding of Rev protein to the primary Rev binding domain (II...
Topics
- Base Sequence
- DNA Probes
- Electrophoresis, Agar Gel
- Gene Products, rev
- Genes, env
- HIV-1
- Humans
- Molecular Sequence Data
- Mutation
- RNA, Viral