Article
Variable Susceptibility to Cigarette Smoke-Induced Emphysema in 34 Inbred Strains of Mice Implicates Abi3bp in Emphysema Susceptibility.
American journal of respiratory cell and molecular biology - 1 Sept 2017
Radder Josiah E, Gregory Alyssa D, Leme Adriana S, Cho Michael H, Chu Yanxia, Kelly Neil J, Bakke Per, Gulsvik Amund, Litonjua Augusto A, Sparrow David, Beaty Terri H, Crapo James D, Silverman Edwin K, Zhang Yingze, Berndt Annerose, Shapiro Steven D
Abstract excerpt
Chronic obstructive pulmonary disease (COPD) is caused by a complex interaction of environmental exposures, most commonly cigarette smoke, and genetic factors. Chronic cigarette smoke exposure in the mouse is a commonly used animal model of COPD. We aimed to expand our knowledge about the variable susceptibility of inbred strains to this model and test for genetic variants associated with this trait. To that end,...
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