Article
Genetic analysis of lung function in inbred mice suggests vitamin D receptor as a candidate gene.
Molecular genetics and genomics : MGG - 1 Oct 2011
Berndt Annerose, Savage H S, Stearns T M, Paigen B
Abstract excerpt
Vitamin D receptor (VDR) polymorphisms are associated with an increased asthma incidence in human populations; however, observations in Vdr knockout mice are unclear. The aim of our study was to determine the influence of the genetic variation in Vdr among inbred strains on lung resistance (i.e., dynamic and airway resistance). In an intercross between the strains C57BL/6J (B6) and KK/HlJ (KK), we identified that...
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