MSH2 deficient mice are viable and susceptible to lymphoid tumours.

doi:10.1038/ng0995-64

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Article

MSH2 deficient mice are viable and susceptible to lymphoid tumours.

Nature genetics - 1 Sept 1995

Reitmair A H, Schmits R, Ewel A, Bapat B, Redston M, Mitri A, Waterhouse P, Mittrücker H W, Wakeham A, Liu B

Abstract excerpt

Alterations of the human MSH2 gene, a homologue of the bacterial MutS mismatch repair gene, co-segregate with the majority of hereditary non-polyposis colon cancer (HNPCC) cases. We have generated homozygous MSH2-/- mice. Surprisingly, these mice were found to be viable, produced offspring in a mendelian ratio and bred through at least two generations. Starting at two months of age homozygous-/- mice began, with...

Topics

Animals
Base Sequence
Cell Transformation, Neoplastic
Colorectal Neoplasms, Hereditary Nonpolyposis
DNA Repair
DNA, Neoplasm
DNA, Satellite
DNA-Binding Proteins
Female
Fungal Proteins
Gene Targeting

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Genotype

Humans

Lymphoid Tissue

Male

Meiosis

Mice

Mice, Knockout

Source

Open in PubMed

Identifiers

PMID: 7550317
DOI: 10.1038/ng0995-64

Genes

MSH2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7550317-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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MSH2 deficient mice are viable and susceptible to lymphoid tumours.PMID 7550317Read ↗

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