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Article

Contributions by MutL homologues Mlh3 and Pms2 to DNA mismatch repair and tumor suppression in the mouse.

Cancer research - 1 Oct 2005

Chen Peng-Chieh, Dudley Sandra, Hagen Wayne, Dizon Diana, Paxton Leslie, Reichow Denise, Yoon Song-Ro, Yang Kan, Arnheim Norman, Liskay R Michael, Lipkin Steven M

Abstract excerpt

Germ line DNA mismatch repair mutations in MLH1 and MSH2 underlie the vast majority of hereditary non-polyposis colon cancer. Four mammalian homologues of Escherichia coli MutL heterodimerize to form three distinct complexes: MLH1/PMS2, MLH1/MLH3, and MLH1/PMS1. Although MLH1/PMS2 is generally thought to have the major MutL activity, the precise contributions of each MutL heterodimer to mismatch repair functions...

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Source

Identifiers

PMID: 16204034
DOI: 10.1158/0008-5472.CAN-05-0742

Genes

MLH1
PMS2
MLH3
MSH2
PMS1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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